Protein Details: G protein-activated inward rectifier potassium channel 4

Protein ID

ICDB_Pro_0557

Protein Name

G protein-activated inward rectifier potassium channel 4

Gene Name

Kcnj5; Girk4

Organism

Rattus norvegicus (Rat)

Length

419 amino acids

AlphaFoldDB

AF-P48548-F1-model_v4.pdb

Function

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised; the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium

Sequence

MAGDSRNAMNQDMEIGVTSQDHKKIPKQARDYIPIATDRTRLLPEGKKPRQRYMEKTGKCNVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTITWLFFGFIWWLIAYVRGDLDHVGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINEKSPFWEMSRAQLEQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTPSCCAKELAEMKRNGQLLQSLPSPPLLGGCAEAEKEAEAEHDEEEEPNGLSVSRATRGSM

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Most abundant in heart tissue where it is found predominantly in atria. Also found in brain; kidney; liver; spleen; lung and thymus.

DOI ID

10.1038/370456a0; 10.1038/378792a0; 10.1038/374135a0; 10.1074/jbc.270.44.26086; 10.1101/gr.2596504

RefSeq

NP_058993.1